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A list of all the posts and pages found on the site. For you robots out there, there is an XML version available for digesting as well.
Pages
Posts
Binomial Theorem’s Insight in a Combinatorics Problem
Published:
An elegant summation that collapses to a surprisingly clean answer once you notice how it mirrors the binomial theorem.
Hello — A Brief Intro
Published:
A snapshot of who I was in my last year of high school, written when I first started this blog.
My First SAT — Test-taking Experience in Macau
Published:
A short travelogue and logistics log from my first SAT, taken at St. Joseph University in Macau. (The original practice-correction screenshots live in my offline study archive and are omitted here.)
Notes on Calculus III — Vector Basics
Published:
My study notes on the vector foundations of Calculus III — length, dot product, cross product, and the inequalities and geometric interpretations that fall out of them.
portfolio
SPADE — Diffusion Surrogates for Offline Optimization
A calibrated conditional-diffusion surrogate with a kNN support prior for offline black-box optimization. Accepted to ICML 2026.
PyTorch · diffusion models · optimization
iGEM — Synthetic Biology (BNDS-China)
Two consecutive gold medals and top-10 high-school team at the International Genetically Engineered Machine competition, as team leader and instructor.
synthetic biology · genetic circuits · dry lab
GNN4Biomed — Graph Learning for Precision Medicine
A graph-convolutional model that predicts drug–disease indications over a biomedical knowledge graph, as a step toward pharmacogenomics-aware recommendation.
PyTorch Geometric · RGCN · PrimeKG
Modeling Southern California Wildfires
A data-driven geography research project analyzing the drivers and spread of wildfires in Southern California.
data analysis · geospatial · modeling
Mathematical Modeling — IMMC & MCM
Outstanding (top <1%) in the 2025 IMMC Greater-China round and Meritorious internationally; MILP scheduling models built and typeset end-to-end.
MILP · PuLP · LaTeX
publications
A Multi-Modal Benchmark for Biomedical Machine-Learning Agents
Benchmark · manuscript in preparation, 2025
An AI-agent framework and curated benchmark that evaluate whether agents can generate correct, runnable code for real biological research tasks across multiple data modalities.
Recommended citation: Yonghan Yang, et al. A Multi-Modal Benchmark for Biomedical Machine-Learning Agents. Manuscript in preparation, 2025–2026.
An Agentic Benchmark for Financial Intelligence
Benchmark · manuscript in preparation, 2026
A benchmark that evaluates LLM agents on realistic financial workflows — trading, hedging, market-insight generation, and auditing — measuring not just final answers but the quality of the reasoning and tool use along the way.
Recommended citation: Yonghan Yang, et al. An Agentic Benchmark for Financial Intelligence. Manuscript in preparation, 2026.
Semi-Supervised High-Order Relation Learning for Drug–Combination–Disease Prediction
Manuscript in preparation, 2026
Predicting and analyzing higher-order drug-combination-disease relationships from a comprehensive dataset, using semi-supervised learning to exploit the large space of unlabeled combinations.
Recommended citation: Yonghan Yang, et al. Semi-Supervised High-Order Relation Learning for Drug–Combination–Disease Prediction. Manuscript in preparation, 2026.
A Survey on Discrete Diffusion Models
Survey · manuscript in preparation, 2026
A comprehensive review of the formulation, training, and applications of discrete diffusion models — unifying notation across masked, uniform, and absorbing-state processes and surveying their use in language, biology, and combinatorial design.
Recommended citation: Yonghan Yang, et al. A Survey on Discrete Diffusion Models. Manuscript in preparation, 2026.
Surrogate-Guided Memory Retrieval for Autonomous Agents
Manuscript in preparation, 2026
Optimizing what an autonomous agent recalls: we train memory retrieval offline with a learned surrogate that scores which past experiences most improve downstream task success, rather than relying on raw semantic similarity.
Recommended citation: Yonghan Yang*, Ye Yuan*, et al. Surrogate-Guided Memory Retrieval for Autonomous Agents. Manuscript in preparation, 2026. (* equal contribution)
Support-Proximity Augmented Diffusion Estimation for Offline Black-Box Optimization
Published in International Conference on Machine Learning (ICML), 2026
SPADE casts forward surrogate modeling as a calibrated conditional diffusion problem and adds a kNN support-proximity prior, so an offline optimizer stays expressive without exploiting unsupported, out-of-distribution regions. We prove the regularizer is equivalent to Bayesian inference under a valid design prior, and it tops Design-Bench and LLM-optimization tasks.
Recommended citation: Yonghan Yang*, Ye Yuan*, Zipeng Sun, Linfeng Du, Bowei He, Haolun Wu, Can Chen, and Xue Liu. (2026). "Support-Proximity Augmented Diffusion Estimation for Offline Black-Box Optimization." International Conference on Machine Learning (ICML 2026). (* equal contribution)
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